Differences between Botox® and Dysport®

A conversational blog with Sarah Burchett, PA-C

 

Most patients are very familiar with the name “Botox®,” as it was the first FDA approved neurotoxin for cosmetic use, and has practically become a household name due to frequent mention in the media.  However, other FDA-approved neurotoxins, called Dysport® and Xeomin®, are also on the market.  All neurotoxins reduce muscle movement where they are injected, which is how they soften wrinkles that are caused by repetitive facial expressions.    So, what are the differences between these products? 

 

Here’s the technical part for my science nerds out there!  Botox®, Dysport®, and Xeomin® are all types of botulinum toxin Type A, but they are manufactured by different companies and are mixed with different carrier molecules, which gives them a slightly different chemical structure.  Essentially, they are different brands of the same thing.  For instance, your car will run on gas from Mobil or Shell, but they are different companies and may have slight differences in composition.  Botox® (onabotulinumtoxinA) is mixed with sodium chloride, a salt, and manufactured by Allergan in a plant located in Ireland. Dsyport® (abobotulinumtoxinA) is mixed with lactose sourced from cow’s milk and manufactured by Galderma in Montreal, Canada.  Xeomin® (incobotulinumtoxinA) is mixed with sucrose and manufactured in Germany by Merz.  

 

What does all this mean in terms of your cosmetic results?  I have personally had all three brands injected into my facial muscles at some point in time and have seen a good result from each, so I don’t feel that one product is superior to another.  I also am confident that all of these brands are equally safe for adult cosmetic use.  Some patients tell me they respond to one brand better than another, and I’m perfectly happy to inject the brand that they prefer.  We know that Dysport® tends to spread out slightly more than Botox® from where it is injected, and for this reason, I suggest Dysport® for use in the crow’s feet.  However, if I am doing small doses on the upper lip for lip eversion, or injecting the DAO to lessen a frowning appearance, I always use Botox® because I don’t want it to spread at all from the exact area where I inject.  Another consideration is the time it takes for the toxin to take effect.  Botox® generally takes 5 to 8 days to set in, and Dysport® is quicker, about 48 hours.  If a patient comes in on Tuesday wanting an effect by the weekend, I suggest Dysport® because there is a chance Botox® won’t even be working by the weekend.  At Zinsser Plastic Surgery, we offer Botox® and Dysport® for your cosmetic preference.  Both companies offer special rewards programs so that you can get rebates and coupons to maintain your regular injections!     

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